Premium
Increased mutagen‐induced chromosome damage in patients with transformed laryngeal pre‐cancerosis
Author(s) -
Gallo Oreste,
Santoro Roberto,
Lenzi Silvia,
Boddi Vieri,
GiovannucciUzielli Mary Luisa
Publication year - 1996
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19961211)68:6<700::aid-ijc2>3.0.co;2-7
Subject(s) - neoplastic transformation , mutagen , carcinogen , bleomycin , clastogen , malignant transformation , pathology , carcinoma , medicine , chromosome , etiology , aneuploidy , gastroenterology , oncology , cancer research , biology , cancer , genetics , carcinogenesis , micronucleus test , toxicity , chemotherapy , gene
Factors that contribute to malignant transformation of laryngeal pre‐neoplastic lesions remain largely unknown. Potential etiological factors may be related to a genetically controlled sensitivity to environmental carcinogens. In this study, we investigated bleomycin‐induced chromosome damage in 15 patients who experienced a malignant transformation of preneoplastic laryngeal lesions during follow‐up, as compared with chromosome fragility in 30 historical controls with no progression of keratoses during a 10‐year follow‐up, in a match‐paired analysis. Chromosomal analysis demonstrated higher sensitivity to clastogens in patients with malignant progression of laryngeal pre‐neoplastic lesions than that of control patients with no evolution of their original laryngeal keratoses ( p = 0.003). Furthermore, among the study patients, chromosome sensitivity was most apparent in non‐tobacco users with malignant transformation of laryngeal disease. Our data suggest that subjects with pre‐neoplastic laryngeal lesion showing increased susceptibility to carcinogens could be at higher risk for development of laryngeal carcinoma. © 1996 Wiley‐Liss, Inc.