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Microsatellite instability in sporadic human breast cancers
Author(s) -
Toyama Tatsuya,
Iwase Hirotaka,
Yamashita Hiroko,
Iwata Hiroji,
Yamashita Toshinari,
Ito Kazuko,
Hara Yasuo,
Suchi Mariko,
Kato Taiji,
Nakamura Takaaki,
Kobayashi Shunzo
Publication year - 1996
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19961115)68:4<447::aid-ijc8>3.0.co;2-0
Subject(s) - microsatellite instability , medicine , breast cancer , oncology , biology , cancer research , microsatellite , cancer , genetics , gene , allele
Human breast‐cancer specimens from 100 patients were analyzed for microsatellite instability (referred to as replication error; RER) at 12 genomic loci on 7 chromosomes, and results were correlated with clinicopathologic characteristics. In 42 of 100 breast‐cancer patients, we investigated whether RER was associated with the amplification of oncogenes and/or suppression of tumor‐suppressor genes. Of the 100 patients, 8 (8%) were RER‐positive at one or more chromosomal loci. The majority of RER‐positive patients had early‐stage disease with ER‐positive tumors, suggesting that RER occurs early in breast tumorigenesis. However, no significant correlation was observed between RER and oncogenes or tumor‐suppressor genes. Thus, the mechanism of RER in sporadic human breast cancer may be independent of the multi‐step carcinogenesis caused by the alterations of oncogenes and tumor‐suppressor genes. © 1996 Wiley‐Liss, Inc.