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Genomic instability in colorectal cancers in Turkey
Author(s) -
Yağci Tamer,
Göksel Süha,
Doğan Öner,
Ozturk Mehmet,
Yurdusev Nevzat
Publication year - 1996
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19961104)68:3<291::aid-ijc4>3.0.co;2-x
Subject(s) - microsatellite instability , genome instability , colorectal cancer , microsatellite , biology , oncology , medicine , cancer , genetics , gene , dna , allele , dna damage
Microsatellite instability in a subset of colorectal cancers from North America, Europe and Japan has been reported. We examined 88 colorectal cancers from Turkish patients. Five different microsatellite loci (1 mono‐ and 4 dinucleotide repeat regions) were tested. Eight tumors displayed replication errors (RERs) with at least 2 different markers. Right‐sided tumors showed significantly higher frequency of microsatellite instability compared with left‐sided tumors. The frequency of RER phenotype was slightly higher in tumors occurring in younger (<50 years old) than in older patients (13% vs. 8%), and there was no association between sex and genomic instability. The frequency of genomic instability in our study group was 9%, whereas the reported frequencies in tumors from other countries varied between 12% and 16%. © 1996 Wiley‐Liss, Inc.