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nm 23 expression in tissue sections and tumor effusion cells of ovarian neoplasms
Author(s) -
Harlozińska Antonina,
Bar Julia K.,
Gerber Jerzy
Publication year - 1996
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19961021)69:5<415::aid-ijc11>3.0.co;2-1
Subject(s) - pathology , effusion , tumor cells , ovarian tissue , medicine , ovarian tumor , ovary , biology , ovarian cancer , cancer research , cancer , surgery
The genetic changes involved in the metastatic process of ovarian epithelial cancer remain undetermined. The expression of nm 23, a putative metastasis‐suppressor gene product, was assessed immunohistochemically in malignant and benign ovarian neoplasms, considering histology of tumors and clinical advancement of disease. Comparison of nm23 protein content in tissue sections and respective cyst and/or ascitic fluid cells was also performed. Significant heterogeneity of nm 23 immuno‐staining was observed, and no correlation with histological subtype of ovarian carcinoma was found. Expression of nm 23 was higher in carcinomas compared with benign tumors. A significant trend to have a higher nm 23 reactivity in ascitic fluid cells vs. primary tumors was observed. Our results indicate that the increase of nm 23 reactivity is activated in the early stages of the disease and that the progression of ovarian carcinoma is accompanied by overexpression of nm23 protein. Our observations did not confirm the postulated role of nm 23 as a suppressor gene in ovarian cancer. © 1996 Wiley‐Liss, Inc.