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Microsatellite instability in latent prostate cancers
Author(s) -
Watanabe Masatoshi,
Imai Hiroshi,
Kato Hiroya,
Shiraishi Taizo,
Ushijima Toshikazu,
Nagao Minako,
Yatani Ryuichi
Publication year - 1996
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19961021)69:5<394::aid-ijc7>3.0.co;2-0
Subject(s) - microsatellite instability , prostate , medicine , prostate cancer , oncology , biology , cancer , microsatellite , genetics , gene , allele
Forty‐seven latent prostate cancers obtained from 46 Japanese men were examined for microsatellite instability (MSI). This study with examination at 23 microsatellite loci revealed replication error (RER) in 11 of the 47 cases (23%), 4 of them showing RER with 2 loci that was defined as MSI. Histological grade was significantly associated with RER; 9 of the 11 RER positive cases were of infiltrative type, and the 4 of them exhibiting MSI were all poorly differentiated. While the frequency of MSI in latent prostate cancer was lower than in clinical cases, it was found in the more aggressive lesions thought most likely to develop into clinical cancers. © 1996 Wiley‐Liss, Inc.