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Overall cancer incidence not increased after prosthetic knee replacement: 14,551 patients followed for 66,622 person‐years
Author(s) -
Lewold Stefan,
Olsson Håkan,
Gustafson Pelle,
Rydholm Anders,
Lidgren Lars
Publication year - 1996
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19960927)68:1<30::aid-ijc6>3.0.co;2-y
Subject(s) - medicine , incidence (geometry) , rheumatoid arthritis , cancer , osteoarthritis , colorectal cancer , surgery , arthroplasty , population , cohort , prosthesis , cancer registry , pathology , physics , alternative medicine , environmental health , optics
It is unknown whether patients as a consequence of prosthetic joint replacement are at a higher risk of developing cancer. We therefore analyzed cancer incidence following prosthetic knee replacement (TKR). The observed cancer incidence in 14,551 patients from the population‐based Swedish Knee Arthroplasty Register who have undergone TKR because of osteoarthrosis (OA, n = 10,120) or rheumatoid arthritis (RA, n = 4431) were compared with the expected cancer incidence for a Swedish reference population. The cohort was followed for a total of 66,622 person‐years. We followed 33% of the patients with OA and 59% of those with RA for more than 5 years. All patients who underwent TKR, whether for OA or for RA, had lower than expected total cancer incidence. We found a markedly low incidence of colorectal carcinoma, especially in patients with RA. Our results do not indicate an increased incidence of cancer following TKR. © 1996 Wiley‐Liss, Inc.