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Susceptibility to human papillomavirus‐associated cervical intra‐epithelial neoplasia is determined by specific HLA DR‐DQ alleles
Author(s) -
Odunsi Kunle,
Terry George,
Ho Linda,
Bell John,
Cuzick Jack,
Ganesan Trivadi S.
Publication year - 1996
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19960904)67:5<595::aid-ijc1>3.0.co;2-p
Subject(s) - allele , human leukocyte antigen , human papillomavirus , biology , medicine , immunology , genetics , antigen , gene
Human papillomaviruses (HPV) play a causative role in the aetiology of cervical intra‐epithelial neoplasia (CIN) and cervical cancer. Human leukocyte antigens (HLA) are important in the regulation of immune response to foreign antigens. The role of genetic variation at the HLA class II loci (DR and DQ) in CIN (HPV 16, 18, 31 and 33 typed) was investigated by PCR DNA amplification and oligonucleotide probe typing of cervical smears from British Caucasian patients (n = 176) and controls (n = 416). The alleles of the DQBI*03, DRBI*04 and DRBI*II loci were strongly associated with susceptibility to CIN. Specifically, the loose‐haplotypes DRBI*040i‐DQBi*0301 and DRBI*1101‐DQBI*0301 were significant and indicated susceptibility. The DQBI*03 locus was more contributory to this association than the DRBI loci. A weak protective effect was shown for the haplotype DRBI*0101‐DQBI*0501. Positive correlation was also observed for HPV‐positive CIN, suggesting that specific HLA class II alleles may be important in determining the immune response to HPV antigens and the risk for CIN after HPV infection. Our results should help in the rational design of vaccines against HPV. © 1996 Wiley‐Liss, Inc.