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Evidence for two distinct tumor‐suppressor gene loci on the long arm of chromosome 11 in human oral cancer
Author(s) -
Uzawa Katsuhiro,
Suzuki Hiroyoshi,
Komiya Akira,
Nakanishi Hiroshi,
Ogawara Katsunori,
Tanzawa Hideki,
Sato Kenichi
Publication year - 1996
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19960807)67:4<510::aid-ijc8>3.0.co;2-v
Subject(s) - loss of heterozygosity , biology , locus (genetics) , genetics , chromosome , tumor suppressor gene , chromosome 17 (human) , gene , chromosome 9 , allele , cancer , carcinogenesis
Loss of heterozygosity (LOH) on human chromosome 11 has been reported in a variety of human cancers. To search for the existence of tumor‐suppressor gene(s) associated with oral squamous cell carcinoma (SCC) on chromosome 11, we have performed high‐resolution deletion mapping in 31 patients with oral SCC using 22 microsatellite markers for this chromosomal region. LOH was observed in 14 of 25 cases (56.0%) that were informative with at least one locus. Most allelic deletions detected in our study were specific to the long arm of the chromosome. Furthermore, the data presented here show 2 distinct, commonly deleted regions. The first region, with frequent LOH, was restricted between markers D11S939 and D11S924 separated by 3 centimorgans (cM) on chromosome 11q23. The second region of common deletion was identified between markers D115912 and D11S910, separated by 7 cM at 11q25. Our results suggest that at least 2 tumor‐suppressor genes involved in the development of oral SCC are present on the long arm of chromosome II. © 1996 Wiley‐Liss, Inc.