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Vimentin expression is not associated with poor prognosis in breast cancer
Author(s) -
Seshadri Ram,
Raymond Wendy A.,
Leong Anthony S.Y.,
Horsfall David J.,
McCaul Kieran
Publication year - 1996
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19960729)67:3<353::aid-ijc8>3.0.co;2-q
Subject(s) - vimentin , breast cancer , oncology , medicine , cancer , expression (computer science) , pathology , cancer research , immunohistochemistry , computer science , programming language
The clinical significance of vimentin intermediate filament (VIF) expression was studied in relation to other established prognostic parameters in primary breast cancer. Archival tumour samples embedded in paraffin were examined by immunohistochemistry with monoclonal antibodies (MAbs) to VIF, p53 protein and cell proliferation marker MIB‐1. The vimentin staining pattern was heterogeneous, but in vimentin‐positive areas > 80% of the tumour cells were positive. There was no association between vimentin expression and tumour size or the number of axillary lymph nodes involved. Vimentin expression was significantly associated with high‐grade tumours, absence of hormone receptors, increased p53 expression and high tumour proliferation fraction as estimated by MIB‐1 count. Despite these associations with several recognised features of tumour aggressiveness, vimentin expression was not associated with increases in risk of relapse or death from breast cancer. © 1996 Wiley‐Liss, Inc.