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Epidemiology of childhood leukemia in Hokkaido, Japan
Author(s) -
Nishi Motoi,
Miyake Hirotsugu,
Takeda Takeo,
Shimada Masako
Publication year - 1996
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19960729)67:3<323::aid-ijc3>3.0.co;2-t
Subject(s) - leukemia , incidence (geometry) , epidemiology , medicine , population , pediatrics , childhood leukemia , standardized mortality ratio , cohort , mortality rate , demography , lymphoblastic leukemia , environmental health , physics , sociology , optics
The population‐based epidemiological indices (crude incidence, survival rate, mortality, etc.) of childhood leukemia (0–14 years of age) from 1969 to 1993 in Hokkaido Prefecture, Japan, were calculated, using data obtained from the Registry of Childhood Malignancies in Hokkaido Prefecture. A total of 1,084 cases of leukemia were diagnosed in the 1969–93 period. The annual incidence of all types of leukemia from 1984 to 1993 was about 4 per 100,000 children aged 0–14 years, with the incidence of ANLL decreasing slightly and that of ALL increasing. The ratio of ALL/ANLL could similarly be seen to be increasing in all age groups. Out of a cohort of 100,000 live births, about 65 children developed leukemia by 14 years of age, and in this longitudinal observation the ratio of ALL/ANLL was increasing. The incidence of ALL and ANLL and the ratio of ALL/ANLL in Japanese children are approaching those of Caucasians. Approximately 80% of the ALL cases were of the LI type (FAB classification), and about 65% of these could be immunologically classified as “common” ALL. The 5‐year survival rate of T‐ and B‐cell ALL cases was 50% or less, while that of “common” ALL cases was about 80%. © 1996 Wiley‐Liss, Inc.