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A risk score for predicting outcome in patients with gastric cancer, based on stage, sialyl‐Tn immunoreactivity and ploidy—a multivariate analysis
Author(s) -
Victorzon M.,
Lundin J.,
Haglund C.,
Nordling S.,
Roberts P. J.
Publication year - 1996
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19960717)67:2<190::aid-ijc7>3.0.co;2-o
Subject(s) - multivariate analysis , univariate , medicine , stage (stratigraphy) , univariate analysis , multivariate statistics , oncology , prognostic variable , cancer , stomach cancer , adenocarcinoma , gastroenterology , biology , statistics , paleontology , mathematics
Abstract Twelve variables were studied for possible prognostic value in 242 patients with adenocarcinoma of the stomach. Eight of these had a statistically significant effect on survival in univariate analyses. A multivariate analysis of 196 patients showed that the most significant differences in survival could be explained by 3 independent variables acting simultaneously, namely stage of disease, Sialyl Tn antigen (STn) expression and aneuploidy of the tumour cells. By adding scores for stage (1–4 points), STn expression (0–1 points) and ploidy (0–1 points) a risk score based on these 3 variables defined the patients into 6 different risk groups with statistically highly significant differences in survival ( x 2 = 107.74, DF = 1, p < 0.0001). Application of the risk score improves the prediction of outcome, may help in choosing patients for different treatment modalities, and allows more accurate stratification in clinical trials. © 1996 Wiley‐Liss, Inc.