Premium
HCV infection and liver cancer mortality in a Japanese population with HTLV‐I
Author(s) -
Stuver Sherri O.,
Okayama Akihiko,
Tachibaobuyoshi,
Tsubouchi Hirohito,
Mueller Nancy E.,
Tabor Edward
Publication year - 1996
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19960703)67:1<35::aid-ijc8>3.0.co;2-0
Subject(s) - medicine , hepatitis c virus , liver cancer , serology , hepatocellular carcinoma , cancer , immunology , population , seroprevalence , hepatitis c , odds ratio , antibody , virology , gastroenterology , virus , environmental health
In a cohort study of human T‐lymphotropic virus type I (HTLV‐I) infection in Japan, 10 cases of liver cancer death occurred from 1984 through 1993. To analyze the role of hepatitis C virus (HCV), which has been associated with an increasing incidence of hepatocellular carcinoma (HCC) in Japan, a nested case‐control study was performed. Five of the 10 liver cancer cases were positive for antibody to HTLV‐I (anti‐HTLV‐I). The possible interaction between HCV and HTLV‐I infections in the etiology of HCC was investigated, with each liver cancer case matched to 5 cohort controls by gender, age, serum sample date and anti‐HTLV‐I status. Using a matched analysis, odds ratios (OR) were generated for the relationship between HCV serologic status and death from liver cancer. Based on second‐generation enzyme immunoassay with confirmation by recombinant immunoblot assay, 8 of 9 cases with adequate serum available (89%) and 9 of 50 (18%) controls were found to be positive for antibody to HCV (anti‐HCV). Liver cancer death was highly associated with anti‐HCV (matched OR = ξ; p < 0.001). Anti‐HTLV‐I seroprevalence was somewhat correlated with HCV infection. However, the high risk of liver cancer death observed for anti‐HCV‐positive individuals in this population did not vary with respect to whether or not the subjects were also infected with HTLV‐I. © 1996 Wiley‐Liss, Inc.