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Prevalence of mucosotropic human papillomaviruses in squamous‐cell carcinomas of the head and neck
Author(s) -
Snijders Peter J. F.,
Scholes Andrea G. M.,
Hart C. Anthony,
Jones Andrew S.,
Vaughan E. David,
Woolgar Julia A.,
Meijer Chris J. L. M.,
Walboomers Jan M. M.,
Field John K.
Publication year - 1996
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19960516)66:4<464::aid-ijc9>3.0.co;2-u
Subject(s) - polymerase chain reaction , human papillomavirus , head and neck , primer (cosmetics) , pathology , epithelium , epidermoid carcinoma , stage (stratigraphy) , medicine , cell , oncology , carcinoma , biology , cancer research , gene , chemistry , genetics , paleontology , surgery , organic chemistry
The prevalence of mucosotropic human papillomavirus (HPV) DNA in 63 squamous‐cell carcinomas (SCC) from different anatomic sites in the head and neck was determined by general primer‐mediated polymerase chain reaction (GP‐PCR). HPV DNA was detected in 20.6% of SCC. Additional type‐specific PCR for HPV 6, 11, 16, 18, 31 and 33 demonstrated the presence of HPV 16 alone in these carcinomas. HPV 16 was also detected in normal epithelium from the resection margins of the majority of HPV‐positive SCC. HPV status did not correlate with tumour site, whether primary or recurrent, TNM stage, metastases, degree of differentiation, smoking or alcohol history, fate or survival. © 1996 Wiley‐Liss, Inc.