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Optimal regimes for local IL‐2 tumour therapy
Author(s) -
Den Otter Willem,
De Groot Jan Willem,
Bernsen Monique R.,
Heintz A. Peter M.,
Maas Riks,
Jan Hordijk Gerrit,
Hill F. W. Graham,
Klein Wim R.,
Ruitenberg E. Joost,
Rutten Victor P. M. G.
Publication year - 1996
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19960503)66:3<400::aid-ijc22>3.0.co;2-d
Subject(s) - medicine
In this report we present studies on optimal regimes for regional IL‐2 therapy, focused on dose, schedule and site of injection. Original data obtained in 2 murine tumour models show that all 3 factors are of importance. Anti‐tumour responses were most effective when IL‐2 was administered regionally 5 to 10 times, at doses ranging from 7,000 to 33,000 IU/day every day or every other day. This resulted in cure rates of more than 40% in mice bearing ascitic tumour that had also disseminated to liver and lungs. The importance of these data is discussed in the light of previous results of our group. These results illustrate that the doses and schedules used in this study are not effective exclusively in these 2 tumour models but may have a more general applicability. ©1996 Wiley‐Liss, Inc.