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Microsatellite instability in transitional cell carcinoma of the urinary tract and its relationship to clinicopathological variables and smoking
Author(s) -
Uchida Toyoaki,
Wang Chunxi,
Wada Chieki,
Iwamura Masatsugu,
Egawa Shin,
Koshiba Ken
Publication year - 1996
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19960422)69:2<142::aid-ijc13>3.0.co;2-b
Subject(s) - microsatellite instability , microsatellite , transitional cell carcinoma , urinary bladder , urinary system , carcinogenesis , metastasis , pathology , carcinoma , medicine , cancer , biology , bladder cancer , urology , gene , genetics , allele
To determine whether microsatellite instability is involved in the development of transitional cell carcinoma (TCC) of the urinary tract, a microsatellite instability assay was carried out using PCR with 9 microsatellite loci. Thirty‐eight TCC samples (30 patients with bladder cancer, 5 with renal pelvic tumors and 3 with ureteral tumors) and 1 lymph node with metastasis were examined. Microsatellite instability was found in 8 of 38 tumors examined, and 3 showed alterations in more than 2 microsatellite loci. All 8 tumors were beyond grade 2 and stage pT2 advanced tumors. Stages pT1‐2 and pT3‐4 patients differed significantly. Microsatellite instability was greater in smokers than non‐smokers, but the differences were not significant. Microsatellite instability in TCC of the urinary tract is rare in superficial tumors but more common in invasive tumors. Microsatellite alterations would thus appear to occur, and possibly be importantly involved, in the tumorigenesis of urinary tract TCC. © 1996 Wiley‐Liss, Inc.