Premium
Genetic counseling and predictive testing for colorectal cancer risk
Author(s) -
Petersen Gloria M.
Publication year - 1996
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19960220)69:1<53::aid-ijc13>3.0.co;2-l
Subject(s) - genetic counseling , genetic testing , medicine , psychological intervention , predictive testing , colorectal cancer , risk assessment , cancer , bioinformatics , genetics , biology , computer science , nursing , computer security
In contrast to our rapidly increasing knowledge of the genetic basis of colorectal cancer and new molecular technologies, we are only in the early stages of characterizing the impact that this information will have on patients, their families and society. From our research and clinical experience with hereditary colorectal cancer syndromes, we have developed a framework for risk assessment that includes criteria for identifying those at higher genetic risk and guidelines for genetic counseling, predictive genetic testing and follow‐up management. More research is needed to optimally translate this framework into wider clinical practice, including characterizing genetic heterogeneity and phenotype correlations, documenting the efficacy of screening and surgical interventions, and maximizing the awareness of health professionals on genetic counseling and the promise and limitations of gene tests. © 1996 Wiley‐Liss, Inc.