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Photodynamic eradication of amelanotic melanoma of the hamster with fast acting photosensitizers
Author(s) -
Dellian Marc,
Richert Clemens,
Gamarra Fernando,
Goetz Alwin E.
Publication year - 1996
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/(sici)1097-0215(19960117)65:2<246::aid-ijc19>3.0.co;2-b
Subject(s) - photosensitizer , photodynamic therapy , hamster , amelanotic melanoma , pharmacokinetics , melanoma , medicine , cancer research , chemistry , photochemistry , organic chemistry
Three porphycenes with fast pharmacokinetics were tested for their ability to photosensitize amelanotic hamster melanoma A‐Mel‐3 at short time intervals after injection. Laser light irradiation was performed at the time of maximal photosensitizer level in tumor tissue. Photodynamic therapy as short as 5 min after injection led to complete local tumor remission at a dosage of 1.4 μmol/kg for the porphycene CBPn. In comparison, Photofrin required 8.4 μmol/kg for local tumor remission in 5 of 6 animals with 24 hr accumulation time after injection. We propose a swift photodynamic protocol which can compete favorably with conventional techniques of tumor treatment. © 1996 Wiley‐Liss, Inc.