Open AccessDetermination of drug‐induced changes in functional MRI signal using a pharmacokinetic model
Author(s) -
Bloom Alan S.,
Hoffmann Raymond G.,
Fuller Scott A.,
Pankiewicz John,
Harsch Harold H.,
Stein Elliot A.
Publication year - 1999
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/(sici)1097-0193(1999)8:4<235::aid-hbm7>3.0.co;2-3
Subject(s) - voxel , functional magnetic resonance imaging , magnetic resonance imaging , hum , brain mapping , brain activity and meditation , neuroscience , pharmacokinetics , computer science , pattern recognition (psychology) , medicine , psychology , artificial intelligence , electroencephalography , pharmacology , radiology , art , performance art , art history
As the applications of functional magnetic resonance imaging (fMRI) expand, there is a need for the development of new strategies for data extraction and analysis that do not require the presentation of stimuli in a repeated on/off pattern. A description and evaluation of a method and computer algorithm for the detection and analysis of brain activation patterns following acute drug administration using fMRI are presented. A waveform analysis protocol (WAP) input function has been developed that is based upon the single‐dose pharmacokinetics of a drug of interest. As a result of this analysis, regional brain activation can be characterized by its localization and intensity of activation, onset of action, time to peak effect, and duration of action. A global statistical test for significant drug effects based upon the probability of a voxel being activated by a saline vehicle injection is applied to grouped data on a voxel by voxel basis. Representative data are presented using nicotine as a prototypical agent. Using this method, statistically significant drug‐induced brain activation has been identified in several key cortical and subcortical brain regions. Hum Brain Mapping 8:235–244, 1999. © 1999 Wiley‐Liss, Inc.