Open AccessIdentifying global anatomical differences: Deformation‐based morphometry
Author(s) -
Ashburner John,
Hutton Chloe,
Frackowiak Richard,
Johnsrude Ingrid,
Price Cathy,
Friston Karl
Publication year - 1998
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/(sici)1097-0193(1998)6:5/6<348::aid-hbm4>3.0.co;2-p
Subject(s) - hum , multivariate statistics , brain morphometry , asymmetry , biology , artificial intelligence , anatomy , neuroscience , psychology , pattern recognition (psychology) , mathematics , computer science , statistics , medicine , magnetic resonance imaging , radiology , physics , quantum mechanics , art , performance art , art history
The aim of this paper is to illustrate a method for identifying macroscopic anatomical differences among the brains of different populations of subjects. The method involves spatially normalizing the structural MR images of a number of subjects so that they all conform to the same stereotactic space. Multivariate statistics are then applied to the parameters describing the estimated nonlinear deformations that ensue. To illustrate the method, we compared the gross morphometry of male and female subjects. We also assessed brain asymmetry, the effect of handedness, and interactions among these effects. Hum. Brain Mapping 6:348–357, 1998. © 1998 Wiley‐Liss, Inc.