Open AccessIn vivo measurement of blood oxygen saturation using magnetic resonance imaging: A direct validation of the blood oxygen level‐dependent concept in functional brain imaging
Author(s) -
Haacke E. Mark,
Lai Song,
Reichenbach Jürgen R.,
Kuppusamy Karthikeyan,
Hoogenraad Frank G.C.,
Takeichi Hiroshige,
Lin Weili
Publication year - 1997
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/(sici)1097-0193(1997)5:5<341::aid-hbm2>3.0.co;2-3
Subject(s) - nuclear magnetic resonance , magnetic resonance imaging , functional magnetic resonance imaging , oxygen , oxygen saturation , blood oxygenation , in vivo , blood oxygen level dependent , saturation (graph theory) , oxygenation , chemistry , blood flow , cerebral blood flow , biomedical engineering , neuroscience , medicine , psychology , radiology , physics , biology , microbiology and biotechnology , mathematics , organic chemistry , combinatorics
A novel noninvasive magnetic resonance imaging (MRI) method was developed to determine in vivo blood oxygen saturation and its changes during motor cortex activation in small cerebral veins. Specifically, based on susceptibility measurements in the resting states, pial veins were found to have a mean oxygen saturation of Y rest = 0.544 ± 0.029 averaged over 14 vessels in 5 volunteers. During activation, susceptibility measurements revealed an oxygen saturation change of ΔY susc = 0.14 ± 0.02. Independent evaluation from blood flow velocity measurements yielded a value of ΔY flow = 0.14 ± 0.04 for this change. These results validate the blood oxygenation level‐dependent (BOLD) model in functional MRI (fMRI). Hum. Brain Mapping 5:341–346, 1997. © 1997 Wiley‐Liss, Inc.