Open AccessUse of anatomical parcellation to catalog and study structure‐function relationships in the human brain
Author(s) -
Tzourio Natalie,
Petit Laurent,
Mellet Emmanuel,
Orssaud Christophe,
Crivello Fabrice,
Benali Karim,
Salamon Georges,
Mazoyer Bernard
Publication year - 1997
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/(sici)1097-0193(1997)5:4<228::aid-hbm4>3.0.co;2-5
Subject(s) - neuroanatomy , hum , functional imaging , brain mapping , neuroscience , artificial intelligence , psychology , computer science , pattern recognition (psychology) , art , performance art , art history
We describe a functional neuroanatomy approach that combines structural (MRI) and functional (PET) data at the individual level. For each subject MRI dataset, sulci are first localized using hemisphere surface rendering and sections and stored. Using these landmarks, the subject brain volume is then divided in 100 anatomical volumes of interest (AVOI). AVOI morphometric measurements are readily obtained as well as functional parameters (CBF) after MRI‐PET alignment. This approach allows structure‐function relationship investigations both at the single case and at the intersubject average level; in addition, individual morphometric and functional parameters can be easily archieved in a database for further meta‐analysis. This approach is applicable to all imaging modalities and is especially suited for a priori hypothesis testing and for the investigation of interindividual functional neuroanatomy variability. Hum. Brain Mapping 5:228–232, 1997. © 1997 Wiley‐Liss, Inc.