Premium
Regulation and execution of apoptosis during Drosophila development
Author(s) -
Bangs Peter,
White Kristin
Publication year - 2000
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/(sici)1097-0177(200005)218:1<68::aid-dvdy6>3.0.co;2-9
Subject(s) - biology , programmed cell death , apoptosis , microbiology and biotechnology , metamorphosis , embryo , embryogenesis , cell , genetics , larva , ecology
The development of the Drosophila embryo into an adult fly is a process that integrates cell proliferation and differentiation with programmed cell death, or apoptosis. Apoptosis is an evolutionarily conserved process that is controlled in the developing fly by the products of the genes reaper , grim , and hid . We discuss the role of programmed cell death in the establishment and maintenance of correct patterning in the embryo, and examine the coordination of apoptosis with the hormonally controlled degeneration of larval tissues during metamorphosis. Finally, we address the architecture of the adult eye as an example of how programmed cell death plays a key role in the development of many adult structures. Dev Dyn;218:68–79. © 2000 Wiley‐Liss, Inc.