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Forkhead transcription factor FoxF2 is expressed in mesodermal tissues involved in epithelio‐mesenchymal interactions
Author(s) -
Aitola Marjo,
Carlsson Peter,
Mahlapuu Margit,
Enerbäck Sven,
PeltoHuikko Markku
Publication year - 2000
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/(sici)1097-0177(200005)218:1<136::aid-dvdy12>3.0.co;2-u
Subject(s) - mesenchyme , biology , transcription factor , in situ hybridization , embryogenesis , mesenchymal stem cell , embryonic stem cell , microbiology and biotechnology , transcription (linguistics) , forkhead transcription factors , embryo , messenger rna , gene , genetics , linguistics , philosophy
The growing family of forkhead transcription factors plays many important roles during embryonic development. In this study we have used in situ hybridization to explore the expression pattern of the forkhead transcription factor gene FoxF2 ( FREAC‐2, LUN ) during mouse and rat embryogenesis, postnatal development, and in adult tissues. We demonstrate that FoxF2 is expressed in the mesenchyme adjacent to the epithelium in alimentary, respiratory, and urinary tracts, similar to FoxF1 ( FREAC‐1, HFH‐8 ). FoxF2 mRNA was also observed in organs that do not express FoxF1 during embryogenesis, e.g., in the central nervous system, eye, ear, and limb buds. In organs that express both FoxF2 and FoxF1 , these transcription factors may have similar functions in epithelio‐mesenchymal crosstalk, but the fact that FoxF2 is more widely expressed than FoxF1 suggests that FoxF2 also has an independent role as a developmental regulator. Dev Dyn;218:136–149. © 2000 Wiley‐Liss, Inc.