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Expression of two ATP‐gated ion channels, P2X 5 and P2X 6 , in developing chick skeletal muscle
Author(s) -
Meyer Martin P.,
GröschelStewart Ute,
Robson Tim,
Burnstock Goeffrey
Publication year - 1999
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/(sici)1097-0177(199912)216:4/5<442::aid-dvdy12>3.0.co;2-z
Subject(s) - myogenesis , skeletal muscle , biology , myocyte , embryo , receptor , dorsal root ganglion , ion channel , microbiology and biotechnology , anatomy , dorsum , endocrinology , genetics
Physiological and pharmacological studies have shown that ATP has potent effects on developing chick skeletal muscle. These effects have previously been shown to be developmentally regulated, and the responses were characteristic of activation of the P2X ligand‐gated ion‐channel family of ATP receptors. Here, using immunohistochemistry, we describe the expression patterns of two members of the P2X receptor family, P2X 5 and P2X 6 , during development of skeletal muscle in the chick embryo. These receptors were first expressed at early stages of skeletal muscle development, and expression disappeared immediately before the stage at which fusion of myoblasts to form myotubes occurs. P2X 5 was also demonstrated in nerves supplying developing skeletal muscle, in some dorsal root ganglion cells, and in dorsal and ventral spinal cord. No expression of the other five members of the P2X family were demonstrated in developing skeletal muscle. Dev Dyn 1999;216:442–449. ©1999 Wiley‐Liss, Inc.