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Expression of Melk , a new protein kinase, during early mouse development
Author(s) -
Heyer Babette S.,
Kochanowski Helga,
Solter Davor
Publication year - 1999
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/(sici)1097-0177(199908)215:4<344::aid-aja6>3.0.co;2-h
Subject(s) - biology , microbiology and biotechnology , expression (computer science) , protein kinase a , kinase , computational biology , computer science , programming language
A new gene named maternal embryonic leucine zipper kinase, Melk , has been recently identified (Heyer et al. [1997] Mol. Reprod. Dev. 47:148–156). As a basis for further study of the function of the gene, we have examined the expression of Melk across a wide range of embryonic stages, from the ovulated egg and 2‐cell embryo through the gastrulation and early organogenesis stages, by in situ hybridization and immunohistochemistry. Melk is expressed in a spatially and temporally specific pattern during mammalian embryogenesis. The strongest expression was detected during maturation of oocytes and preimplantation development. Given its expression pattern, Melk may play an important role during preimplantation embryonic development. Dev Dyn 1999;215:344–351. © 1999 Wiley‐Liss, Inc.