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Dynamics of placodal lineage development revealed by targeted transgene expression
Author(s) -
Hatini Victor,
Ye Xin,
Balas Gabriela,
Lai Eseng
Publication year - 1999
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/(sici)1097-0177(199908)215:4<332::aid-aja5>3.0.co;2-r
Subject(s) - biology , transgene , lineage (genetic) , computational biology , genetics , dynamics (music) , microbiology and biotechnology , gene , physics , acoustics
Examination of the expression pattern of the winged‐helix transcription factor BF‐1 outside of the neural tube in mouse embryos suggests that BF‐1 is restricted to a population of cells that gives rise to the ectodermal placodes and their derivatives. Within the sensory cranial nerve ganglia, the expression of BF‐1 distinguishes cells that arise from the placodes from those derived from the neural crest. Expression of a lacZ transgene targeted to the BF‐1 locus was used to follow the placodal lineage during mouse development. Analysis of placodal development in mice with a targeted deletion of BF‐1 reveals that, although BF‐1 is required for proliferation of the cells arising from the nasal placode, it is not required for the proliferation, survival, or both, of placode‐derived cells in the sensory cranial nerve ganglia. Dev Dyn 1999;215:332–343 . © 1999 Wiley‐Liss, Inc.