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AmphiBMP2/4, an amphioxus bone morphogenetic protein closely related to Drosophila decapentaplegic and vertebrate BMP2 and BMP4: Insights into evolution of dorsoventral axis specification
Author(s) -
Panopoulou Georgia D.,
Clark Matthew D.,
Holland Linda Z.,
Lehrach Hans,
Holland Nicholas D.
Publication year - 1998
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/(sici)1097-0177(199809)213:1<130::aid-aja13>3.0.co;2-6
Subject(s) - decapentaplegic , biology , ectoderm , vertebrate , anatomy , morphogenesis , primordium , microbiology and biotechnology , bone morphogenetic protein 4 , lateral plate mesoderm , bone morphogenetic protein , homeobox , sonic hedgehog , mesoderm , imaginal disc , embryo , embryogenesis , embryonic stem cell , transcription factor , genetics , drosophila melanogaster , gene , signal transduction
Amphioxus AmphiBMP2/4 appears to be a single gene closely related to vertebrate BMP2 and BMP4 . In amphioxus embryos, the expression patterns of AmphiBMP2/4 suggest patterning roles in the ectodermal dorsoventral axis (comparable to dorsoventral axis establishment in the ectoderm by Drosophila decapentaplegic and vertebrate BMP4 ). In addition AmphiBMP2/4 may be involved in somite evagination, tail bud growth, pharyngeal differentiation (resulting in club‐shaped gland morphogenesis), hindgut regionalization, differentiation of olfactory epithelium, patterning of the anterior central nervous system, and establishment of the heart primordium. One difference between the developmental role of amphioxus AmphiBMP2/4 and vertebrate BMP4 is that the former does not appear to be involved in the initial establishment of the dorsoventral polarity of the mesoderm. Dev. Dyn. 1998;213:130–139. © 1998 Wiley‐Liss, Inc.