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Embryonic implantation in galectin 1/galectin 3 double mutant mice
Author(s) -
Colnot Céline,
Fowlis Deborah,
Ripoche MarieAnne,
Bouchaert Isabelle,
Poirier Françoise
Publication year - 1998
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/(sici)1097-0177(199804)211:4<306::aid-aja2>3.0.co;2-l
Subject(s) - galectin , biology , galectin 1 , embryo , mutant , blastocyst , galectin 3 , embryonic stem cell , microbiology and biotechnology , embryogenesis , gene targeting , gene , andrology , genetics , immunology , medicine
Galectin 1 and galectin 3 are first expressed in the trophectoderm cells of the implanting embryo and have been implicated in the process of implantation. However, we had previously shown that the lack of galectin 1 in galectin 1 null mutant mice is compatible with implantation. In this study, we describe the generation of galectin 3 null mutant mice and show that they are viable and have no overt abnormalities. The importance of galectin 1 and galectin 3 in implantation was assessed by obtaining double mutant mice [gal1 −/−; gal3 −/−]. We find that implantation can still occur in the absence of both galectin 1 and galectin 3. However, we show that galectin 5, a third member of this gene family, is also present in the blastocyst at the time of implantation. Dev. Dyn. 1998;211:306–313. © 1998 Wiley‐Liss, Inc.