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Expression of murine Lhx 5 suggests a role in specifying the forebrain
Author(s) -
Sheng Hui Z.,
Bertuzzi Stefano,
Chiang Chin,
Shawlot William,
Taira Masanori,
Dawid Igor,
Westphal Heiner
Publication year - 1997
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/(sici)1097-0177(199702)208:2<266::aid-aja13>3.0.co;2-1
Subject(s) - forebrain , biology , hindbrain , neural tube , homeobox , diencephalon , neural plate , cerebrum , dlx5 , zebrafish , midbrain , microbiology and biotechnology , xenopus , gene , neuroscience , genetics , gene expression , embryo , central nervous system
A LIM homeobox gene, Lim 5, is known to be expressed in the forebrain of Xenopus and zebrafish (Toyama et al. [1995] Dev. Biol. 170:583–593). Results from developmental and comparative studies of its mouse ortholog, Lhx 5, indicate that this gene may play important roles in forebrain development. Lhx 5 expression is detected in the most anterior portion of the neural tube at the headfold stage, overlapping partially with Otx 2 expression domain. After neural tube closure, Lhx 5 is expressed as a transverse stripe, covering most of the diencephalic primordium. This expression recedes to restricted areas as Dlx gene expression occurs. By midgestation, both genes, Lhx 5 and Dlx 5, are expressed in the diencephalon and ventral telencephalon in an alternating complementary pattern. It may be that Dlx inhibits Lhx 5, and this may represent a step of early regionalization of the forebrain. Lhx 5 is also expressed in midbrain, hindbrain, and spinal cord, overlapping extensively with Lhx 1 starting from day E10.5 of gestation. The early, persistent, and dynamic expression of Lhx 5 suggests a regulatory function in forebrain formation. Dev. Dyn. 208:266–277, 1997. © Wiley‐Liss, Inc. This article is a government work and, as such, is in the public domain.