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A clinicopathologic study of gastric mucosa‐associated lymphoid tissue lymphoma
Author(s) -
Ohashi Shinji,
Segawa Kose,
Okamura Shozo,
Urano Humihiro,
Kanamori Shinichi,
Ishikawa Hideki,
Hara Kazuo,
Hukutomi Akira,
Shirai Kennosuke,
Maeda Matsuyoshi
Publication year - 2000
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(20000515)88:10<2210::aid-cncr3>3.0.co;2-i
Subject(s) - proliferating cell nuclear antigen , medicine , malt lymphoma , lymphoma , helicobacter pylori , immunohistochemistry , submucosa , lymphatic system , pathology , mucosa associated lymphoid tissue , gastric mucosa , gastroenterology , lymph node , stomach
BACKGROUND It is still unclear which patients with gastric mucosa‐associated lymphoid tissue (MALT) lymphoma will benefit from the eradication of Helicobacter pylori.METHODS The authors studied a total of 34 patients. Twenty‐three patients had primary gastric lymphoma and underwent gastric resection as initial treatment. Eleven patients with gastric MALT lymphoma who received antibiotics against H. pylori as initial treatment were also included. In all 34 patients, the presence of H. pylori, endoscopic findings, and pathologic features were evaluated. Immunohistochemical expression of Bcl‐2, p53, and proliferating cell nuclear antigen (PCNA) was classified as follows: (−), no reactive cells; (+), scattered positive cells; (2+), nests of positive cells; (3+), diffuse positive cells. RESULTS Patients with low grade MALT lymphoma (LG) tended to be positive for H. pylori (6 of 9), to localize within the submucosa (7 of 9), not to have lymph node involvement (7 of 8), and to have lower tumor stage compared with patients with high grade MALT components (HG). Bcl‐2 protein was expressed with high frequency by LG (7 of 9). Strong expression of p 53 was more common in the HG tumors (4 of 14), and strong expression of PCNA showed a significant difference between LG (1 of 8) and HG patients (12 of 13). Investigation of the patients with long term follow‐up (n = 4) revealed that LG remained superficial for a long time and showed gradual progression. Most of these tumors were Bcl‐2+/p53−∼±/PCNA−∼+. There were two patients whose superficial LG (sm/Bcl‐2+/p53−/PCNA−∼+) regressed after the disappearance of H. pylori. On the other hand, one patient developed ulcerated LG (sm/Bcl‐2−/p53+/PCNA3+) after disappearance of H. pylori. The authors found complete regression of MALT lymphoma in 9 of 11 patients after H. pylori eradication. Initial tumors of these 9 patients were superficial/sm/n(−)/low grade/Bcl‐2+∼±/p53−∼+ (n = 9), /PCNA−∼+(n = 6), /PCNA 2+ (n = 3). Two local recurrence and one non‐Hodgkin lymphoma in other sites were observed after initial therapy. CONCLUSIONS Gastric MALT lymphoma with ( H. pylori positive/superficial/sm/low grade/Bcl‐2+/p53−∼+/PCNA−∼+) pattern will disappear after a patient is cured of H. pylori infection. Cancer 2000;88:2210–9. © 2000 American Cancer Society.