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Diagnosis of lymphoma by fine‐needle aspiration cytology using the revised European–American classification of lymphoid neoplasms
Author(s) -
Young Nancy A.,
AlSaleem Tahseen
Publication year - 1999
Publication title -
cancer cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19991225)87:6<325::aid-cncr3>3.0.co;2-w
Subject(s) - medicine , lymphoma , immunophenotyping , fine needle aspiration , pathology , context (archaeology) , cytology , fine needle aspiration cytology , radiology , biopsy , immunology , paleontology , flow cytometry , biology
BACKGROUND Recent changes in the classification of non‐Hodgkin lymphoma (NHL) emphasize the diagnostic importance of cytomorphology, immunophenotyping, and molecular findings in addition to histology. These changes have allowed for a greater role of fine‐needle aspiration cytology (FNA) in the diagnosis of NHL. METHODS A review of the English language literature regarding the use of FNA in the cytodiagnosis of lymphoma was performed. The revised European–American classification of lymphoid neoplasms (REAL) was reviewed in the context of its adaptability to the cytologic diagnosis of lymphoid neoplasms. RESULTS FNA is being used more frequently in the diagnosis, staging, and follow‐up of lymphoma whenever supportive studies are readily available. Cytomorphologic, immunophenotypic, and molecular criteria as well as pitfalls in the diagnosis of lymphoma by FNA have been delineated. Information was compiled into tables to facilitate correlation of criteria with the proposed REAL system. CONCLUSIONS Many cases of NHL can be diagnosed and subclassified by FNA when there is adequate immunophenotypic information. [See editorial on pages 322–4, this issue.] Cancer (Cancer Cytopathol) 1999;87:325–45. © 1999 American Cancer Society.