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The development of new brain tumor therapy utilizing the local and sustained delivery of chemotherapeutic agents from biodegradable polymers
Author(s) -
Brem Henry,
Lawson H. Christopher
Publication year - 1999
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19990715)86:2<197::aid-cncr2>3.0.co;2-6
Subject(s) - medicine , microsphere , chemotherapeutic drugs , drug delivery , pharmacology , brain cancer , drug , delivery system , chemotherapy , cancer , surgery , nanotechnology , materials science , chemical engineering , engineering
The local delivery of 5‐fluorouracil by polymeric microspheres is a safe method with which to achieve sustained concentrations of a chemotherapeutic agent in the brain. Further clinical studies are needed to evaluate the effect of drug‐loaded microspheres as radiosensitizers and antitumor agents. See also pages 325–30.