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Epithelial ovarian carcinoma in the reproductive age group
Author(s) -
Duska Linda R.,
Chang YuChiao,
Flynn Cynthia E.,
Chen Annette H.,
Goodman Annekathryn,
Fuller Arlan F.,
Nikrui Najmosama
Publication year - 1999
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19990615)85:12<2623::aid-cncr19>3.0.co;2-o
Subject(s) - medicine , infertility , carcinoma , proportional hazards model , stage (stratigraphy) , epithelial ovarian carcinoma , univariate analysis , survival rate , oncology , ovarian carcinoma , survival analysis , gynecology , prognostic variable , multivariate analysis , cancer , ovarian cancer , pregnancy , paleontology , genetics , biology
BACKGROUND A retrospective review of women age ≤ 40 years with epithelial ovarian carcinoma was undertaken to determine whether patient age and tumor grade are independent prognostic factors for survival, to investigate the survival rate for young women with ovarian carcinoma, and to characterize these young women in terms of reproductive capability. METHODS The tumor registry of the Massachusetts General Hospital was used to identify cases of ovarian carcinoma diagnosed between January 1980 and July 1996. Patient records and pathology were reviewed. Survival rates were calculated by the Kaplan–Meier method and Cox proportional hazards models were used to determine the independent effect of each variable on survival. RESULTS Ninety‐two tumors epithelial tumors were identified with 46 (50%) classified as borderline. In the univariate analysis, stage ( P < 0.001), grade ( P < 0.001), residual disease (≤ 2 cm vs. > 2 cm, P < 0.001), and age (< 30 years vs. 31–40 years; P = 0.019) were found to be significant prognostic factors for survival. However, in the multivariate analysis only tumor grade (with borderline tumors assigned a grade of 0) and stage were significant predictors of survival ( P < 0.01 for both). The 5‐year survival rate for carcinoma patients with advanced disease was 22.9%. Patients with borderline tumors were more likely be diagnosed during an evaluation for infertility and were more likely to have successful live births after carcinoma treatment. CONCLUSIONS Young women with advanced epithelial carcinoma have a 5‐year survival rate similar to that quoted in the literature, despite the use of more aggressive chemotherapeutic regimens. Patients with borderline tumors of any stage have an excellent prognosis for preserving fertility options. Cancer 1999;85:2623–9. © 1999 American Cancer Society.