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Evidence of intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells
Author(s) -
Mourant Judith R.,
Hielscher Andreas H.,
Eick Angelia A.,
Johnson Tamara M.,
Freyer James P.
Publication year - 1998
Publication title -
cancer cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19981225)84:6<366::aid-cncr9>3.0.co;2-7
Subject(s) - scattering , light scattering , carcinogenesis , medicine , cancer cell , cancer , wavelength , optics , physics
BACKGROUND The objective of this study was to determine whether there are intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells from a multistep carcinogenesis model. METHODS Wavelength‐dependent and polarization‐dependent light scattering properties of cell suspensions were measured. RESULTS Statistically significant differences were found between the tumorigenic and nontumorigenic cells. CONCLUSIONS Differences in the light scattering properties of tumorigenic and nontumorigenic cells are attributed to a change in the average size of the scattering centers on the order of a few ten of nanometers. This work is relevant to the development of noninvasive optical methods for cancer diagnosis. Cancer (Cancer Cytopathol) 1998;84:366‐374. © 1998 American Cancer Society.