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Angiogenesis in adenocarcinoma of the uterine cervix
Author(s) -
Kaku Tsunehisa,
Hirakawa Toshio,
Kamura Toshiharu,
Amada Satoshi,
Kinukawa Naoko,
Kobayashi Hiroaki,
Sakai Kunihiro,
Ariyoshi Kazuya,
Sonoda Kenzo,
Nakano Hitoo
Publication year - 1998
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19981001)83:7<1384::aid-cncr16>3.0.co;2-0
Subject(s) - medicine , angiogenesis , adenocarcinoma , stage (stratigraphy) , cervix , metastasis , pathology , microvessel , oncology , cancer , biology , paleontology
BACKGROUND Angiogenesis is essential for tumor growth, progression, and metastases. Microvessel density (MVD), a measure of tumor angiogenesis, has been found to have prognostic significance in many tumor types for predicting metastasis and survival. METHODS Between 1979‐1989, 56 cases of FIGO Clinical Stage I and II adenocarcinoma of the uterine cervix treated by hysterectomy were reviewed histologically. All hysterectomy specimens were stained immunohistologically for factor VIII‐related antigen. MVD was counted in a x200 field ( 0.785 mm 2 per field) in the most active area of neovascularization. Results were expressed as the highest number of microvessels identified within any single x200 field. MVD and several other prognostic parameters were examined for correlation with progression free survival (PFS) and overall survival (OS) by a multivariate analysis according to the Cox proportional hazards model. RESULTS In early adenocarcinoma of the uterine cervix, MVD was increased significantly in invasive areas compared with adjacent nonneoplastic areas (median: 62.5 [range, 30‐105] vs. median: 36.5 [range, 23‐47]; P = 0.0003). MVD also was significantly correlated with ascites cytology ( P = 0.0377). There was no correlation between microvessel count and lymph node status, depth of invasion, disease stage, lymph‐vascular space invasion, grade, or parametrial involvement. Patients with high MVD (≥ 75) had significantly worse PFS and OS than those with low MVD (< 75) (log rank test, P = 0.0180 and 0.0199, respectively). Multivariate analysis showed that MVD correlated significantly and independently with PFS and OS. CONCLUSIONS In adenocarcinoma of the cervix, MVD is an independent prognostic factor for PFS and OS. Cancer 1998;83:1384‐1390. © 1998 American Cancer Society.