Premium
Long term survival of patients with stage IV gastric carcinoma
Author(s) -
Kakeji Yoshihiro,
Maehara Yoshihiko,
Tomoda Masaaki,
Kabashima Akira,
Ohmori Mariko,
Oda Shinya,
Ohno Shinji,
Sugimachi Keizo
Publication year - 1998
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19980615)82:12<2307::aid-cncr2>3.0.co;2-p
Subject(s) - medicine , gastrectomy , lymphovascular invasion , lymph node , cancer , stage (stratigraphy) , proliferating cell nuclear antigen , gastroenterology , pathology , carcinoma , lymphatic system , immunohistochemistry , metastasis , biology , paleontology
BACKGROUND Survival of patients with Stage IV (based on general rules established by the Japanese Research Society for Gastric Cancer) gastric carcinoma often is unfavorable. Among patients with a poor prognosis, a few do survive > 5 years. The authors examined pathologic and biologic features of tumors of long term survivors. METHODS The authors analyzed data from 442 patients with Stage IV gastric carcinoma, including 20 surviving for > 5 years after gastrectomy (Group A) and 422 who died of gastric carcinoma within 5 years (Group B). Mutant p53 was immunohistochemically stained using the monoclonal antibody PAb1801. Proliferative activity was estimated by argyrophilic nuclear organizer region (AgNOR) staining and proliferating cell nuclear antigen (PCNA) staining. RESULTS Group A had smaller and more localized tumors than Group B ( P < 0.05 and P < 0.01, respectively). Lymphatic or venous invasion and peritoneal dissemination were less frequent in Group A than in Group B ( P < 0.01). Abnormalities of p53 expression were found in 3 of the 14 tumors in Group A (21%), a value significantly lower than the 58 of 118 tumors in Group B (49%; P < 0.05). AgNOR count and percentage of PCNA labeling were not significantly different between Groups A and B. A multivariate analysis showed that lymph node dissection, liver metastasis, gastric resection, venous invasion, and tumor size were independent prognostic factors. CONCLUSIONS Even in patients with Stage IV gastric carcinoma, radical gastrectomy and extensive lymph node dissection can lead to long term survival. The authors believe that combination analysis of pathologic features and p53 overexpression predict length of survival for patients with Stage IV gastric carcinoma. Cancer 1998;82:2307‐2311. © 1998 American Cancer Society.