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Assessment of pulmonary and cardiac function after high dose chemotherapy with BEAM and peripheral blood progenitor cell transplantation
Author(s) -
Salloum Emile,
Jillella Anand P.,
Nadkarni Rajani,
Seropian Stuart,
Hu Grace L.,
D'Andrea Elizabeth,
Zelterman Daniel,
Cooper Dennis L.
Publication year - 1998
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19980415)82:8<1506::aid-cncr12>3.0.co;2-8
Subject(s) - medicine , transplantation , pulmonary function testing , dlco , vital capacity , cardiology , pulmonary toxicity , surgery , diffusing capacity , lung , lung function
BACKGROUND Limited information is available regarding the cardiac and pulmonary effects of high dose chemotherapy (HDCT) and autologous peripheral blood progenitor cell (PBPC) transplantation. METHODS The authors evaluated cardiac and pulmonary function after BEAM (BCNU 300 mg/m 2 , etoposide 400 mg/m 2 /day x 3 days, cytosine arabinoside 200 mg/m 2 /day x 4 days, and melphalan 140 mg/m 2 ), HDCT, and PBPC transplantation in 26 patients with non‐Hodgkin's lymphoma or Hodgkin's disease. Therapy prior to BEAM included doxorubicin (25 patients), bleomycin (6 patients), and mediastinal irradiation (4 patients). All patients had pulmonary function tests (PFTs) and equilibrium radionuclide angiography before and at a median of 57 weeks after transplantation. RESULTS Prior to high dose therapy, 8 patients had abnormal PFTs, including 6 with a diffusing capacity of the lung for carbon monoxide (DLCO) <70% of predicted value. At the time of reevaluation after HDCT, all patients included in the study were in complete remission, and none had received additional therapy after transplantation. At a median of 77 weeks after transplantation, none of the patients had cardiac or pulmonary symptoms. Moreover, there were no significant changes in total lung capacity, forced vital capacity, forced expiratory volume in 1 second/forced vital capacity, DLCO, or left ventricular ejection fraction values when compared with baseline studies. CONCLUSIONS The authors concluded that HDCT with BEAM and PBPC transplantation did not result in significant cardiac or pulmonary toxicity, even in patients with borderline pretransplantation PFT values. Further studies of patients undergoing HDCT and PBPC transplantation are needed. Cancer 1998;82:1506‐12. © 1998 American Cancer Society.