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The clinicopathologic significance of small areas unstained by lugol's iodine in the mucosa surrounding resected esophageal carcinoma
Author(s) -
Nakanishi Yukihiro,
Ochiai Atsushi,
Yoshimura Kimio,
Kato Hoichi,
Shimoda Tadakazu,
Yamaguchi Hajime,
Tachimori Yuji,
Watanabe Hiroshi,
Hirohashi Setsuo
Publication year - 1998
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19980415)82:8<1454::aid-cncr4>3.0.co;2-9
Subject(s) - medicine , carcinoma , iodine , pathology , metallurgy , materials science
BACKGROUND Small areas unstained with Lugol's iodine are often observed in the mucosa surrounding esophageal carcinomas. METHODS For light microscopic evaluation, the histologic features of 131 small areas unstained by Lugol's iodine in 12 selected cases were investigated. For clinicopathologic evaluation, the numbers of small areas unstained by Lugol's iodine in the mucosa surrounding 147 consecutively resected esophageal carcinomas, including these 12 cases, were counted. The relation between the incidence of such areas and the development of multiple primary cancers in the upper aerodigestive tract was examined together with data on the patients' tobacco and alcohol consumption. RESULTS Ninety‐two percent (131) of the small areas unstained by Lugol's iodine contained dysplastic lesions. Seventeen (12%) of the 147 resected specimens contained fewer than 5 small unstained areas, whereas 52 (35%) had 6‐10 and 78 (53%) had more than 11 such areas. The incidence of multicentric cancer in the upper aerodigestive tract and the average alcohol index scores were significantly higher for patients who had more than 11 unstained areas than for patients who had fewer than 5 such areas ( P < 0.01). CONCLUSIONS Lugol's iodine staining method is useful for detecting groups at high risk of multicentric cancer in the upper aerodigestive tract. Cancer 1998;82:1454‐9. © 1998 American Cancer Society.