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Prognostic value of cyclin E and p53 expression in gastric carcinoma
Author(s) -
Sakaguchi Teruyuki,
Watanabe Akihiko,
Sawada Hidetomo,
Yamada Yukishige,
Yamashita Jun,
Matsuda Masahiko,
Nakajima Masakazu,
Miwa Takeshi,
Hirao Tomoko,
Nakano Hiroshige
Publication year - 1998
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19980401)82:7<1238::aid-cncr5>3.0.co;2-b
Subject(s) - cyclin e , medicine , cyclin , cyclin b , cancer research , cancer , immunohistochemistry , carcinogenesis , cyclin d1 , cyclin d , cell cycle , pathology , oncology
BACKGROUND Cyclins and wild‐type p53 are prime cell cycle regulators and may be involved in tumorigenesis. Cyclin E is a late G 1 cyclin and its abnormalities have been reported in several cancers. The authors investigated the correlation between cyclin E expression and progression of gastric carcinoma. METHODS The expression of cyclin E and p53 proteins was investigated retrospectively in 116 patients with gastric carcinoma. Immunohistochemical staining of the paraffin sections was performed using monoclonal antibodies to cyclin E and p53. RESULTS The total cyclin E positive rate was 44.0% (51 of 116) of all cases, 26 of which were strongly positive. Strong cyclin E expression frequently was observed in deeply invasive tumors, tumors with lymph node metastasis, and tumors of advanced stage. The incidence of p53 expression was higher in the cyclin E positive tumors than in the other tumors. With regard to prognosis, patients whose tumors had both strong positivity for cyclin E and positivity for p53 had significantly poorer prognosis. In multivariate analysis, the combined variable of cyclin E and p53 was an independent prognostic indicator together with serosal invasion and tumor size. CONCLUSIONS These data suggest the cyclin E expression correlates with p53 expression and may contribute to the progression of gastric carcinoma. The combined variable of cyclin E and p53 expression could be a useful prognostic indicator in patients with gastric carcinoma. Cancer 1998;82:1238‐43. © 1998 American Cancer Society.