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Primary sclerosing cholangitis and colorectal carcinoma in patients with chronic ulcerative colitis
Author(s) -
Nuako Kofi W.,
Ahlquist David A.,
Sandborn William J.,
Mahoney Douglas W.,
Siems Diane M.,
Zinsmeister Alan R.
Publication year - 1998
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19980301)82:5<822::aid-cncr4>3.0.co;2-l
Subject(s) - ulcerative colitis , medicine , primary sclerosing cholangitis , gastroenterology , colorectal cancer , odds ratio , risk factor , colitis , carcinoma , confidence interval , case control study , cancer , disease
BACKGROUND Controversy persists regarding primary sclerosing cholangitis (PSC) as a risk factor for colorectal carcinoma in patients with chronic ulcerative colitis. Small sample size and differing endpoints have contributed to variation among reported studies. This large case‐control study was conducted to examine the possible association between PSC and colon carcinoma in patients with ulcerative colitis. METHODS From Mayo Clinic records spanning 1976‐1994, 171 cases with both ulcerative colitis and colorectal carcinoma and 171 contemporaneous controls with ulcerative colitis but no colorectal neoplasia matched with regard to age, gender, extent, and duration of colitis were identified. The diagnosis of PSC required cholangiographic confirmation. Analysis employed a multivariate logistic regression model. RESULTS The prevalence of PSC was similar in cases (18%) and controls (15%) ( P = 0.54). The adjusted odds ratio for colorectal carcinoma with PSC was 1.23 (95% confidence interval, 0.62‐2.42). CONCLUSIONS Based on this large case‐control study, there was no association between PSC and colorectal carcinoma in patients with ulcerative colitis. Cancer 1998;82:822‐6. © 1998 American Cancer Society.