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Ultrasound‐guided fine‐needle aspiration cytology of nonpalpable breast lesions
Author(s) -
Klijanienko Jerzy,
Côté JeanFrançois,
Thibault Fabienne,
Zafrani Brigitte,
Meunier Martine,
Clough Krishna,
Asselain Bernard,
Vielh Philippe
Publication year - 1998
Publication title -
cancer cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19980225)84:1<36::aid-cncr6>3.0.co;2-d
Subject(s) - medicine , radiology , biopsy , ultrasound , breast cancer , fine needle aspiration , fine needle aspiration cytology , cytology , medical diagnosis , open biopsy , cancer , pathology
BACKGROUND The value of ultrasound‐guided fine‐needle aspiration cytology (FNAC) in the diagnosis of nonpalpable breast lesions remains a subject of debate. To determine the accuracy of this procedure in these lesions, a comparative analysis with open surgical biopsy in 188 patients was performed. METHODS Six hundred and fifty‐four nonpalpable breast lesions detected by ultrasound in 585 patients were subjected to FNAC. Of these, 198 lesions (30.3%) from 188 patients were surgically excised. RESULTS Histologically, 105 lesions (53%) were malignant and 93 (47%) were benign. Among carcinomas, 65 cases (61.9%) were concordant, whereas 21 cases (20%) were suspicious, 12 cases (11.4%) were false‐negative (benign), and 7 cases (6.7%) were unsatisfactory for diagnosis. Among benign lesions, 80 cases (86%) were concordant, whereas 5 cases (5.4%) were suspicious, and 8 cases (8.6%) were unsatisfactory. No false‐positive diagnoses were made. The sensitivity of the FNAC method was 87.8%, the specificity was 94.5%, and the positive predictive value was 94.6%. CONCLUSIONS These results indicate that, with the exception of random microcalcified lesions, ultrasound‐guided FNAC is a valuable and reliable technique in the diagnosis of nonpalpable breast lesions. Cancer (Cancer Cytopathol) 1998;84: 36‐41. © 1998 American Cancer Society.