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Nerve lesions after therapy for childhood acute lymphoblastic leukemia
Author(s) -
HarilaSaari Arja H.,
Vainionpää Leena K.,
Kovala Tero T.,
Tolonen E. Uolevi,
Lanning B. Marjatta
Publication year - 1998
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19980101)82:1<200::aid-cncr25>3.0.co;2-5
Subject(s) - medicine , somatosensory evoked potential , acute lymphocytic leukemia , vincristine , anesthesia , spinal cord , chemotherapy , central nervous system , brachial plexus , tibial nerve , surgery , leukemia , cyclophosphamide , stimulation , lymphoblastic leukemia , psychiatry
BACKGROUND The objective of the current study was to use somatosensory evoked potentials (SEP) to detect signs of nerve lesions in the peripheral nerve and in the central nervous system (CNS) after 3 years of treatment for childhood acute lymphoblastic leukemia (ALL). METHODS The somatosensory potentials evoked by stimulation of the median nerve and posterior tibial nerve were recorded in 31 children with ALL after 3 years of therapy. All patients were examined clinically. The 14 standard risk patients had been treated with chemotherapy according to the Nordic regimen, and the 17 intermediate risk or high risk patients had been treated with chemotherapy and cranial irradiation according to the ALL BFM‐83 protocol. RESULTS A decrease in amplitudes was observed at the brachial plexus and spinal cord (C7) in the median SEP, and at the knee, spinal cord (Th12), and cortex in the tibial SEP, indicating axonal injury within the entire CNS in the patients with ALL compared with healthy age‐, gender‐, and height‐matched controls. Prolongation of the SEP latencies was found within the spinal cord, indicating demyelination. These SEP changes had persisted for 2 years since the last injection/infusion of vincristine or methotrexate, which are the principal neurotoxic drugs used in chemotherapy for ALL. Clinical signs of nerve injury such as depressed deep tendon reflexes and gross or fine motor difficulties were found in approximately 33% of the patients and dysdiadochokinesia in 50%. CONCLUSIONS Treatment of ALL in children principally with vincristine and methotrexate causes long‐standing axonal injury throughout the nervous system and demyelination within the spinal cord. These changes are associated with clinical neurologic findings. Cancer 1998;82:200‐7. © 1998 American Cancer Society.