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Borderline tumors of the ovary
Author(s) -
Gotlieb Walter H.,
Flikker Sharon,
Davidson Ben,
Korach Yaacov,
Kopolovic Juri,
BenBaruch Gilad
Publication year - 1998
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19980101)82:1<141::aid-cncr17>3.0.co;2-2
Subject(s) - medicine , fertility , pregnancy , malignancy , retrospective cohort study , conservative management , disease , surgery , ovary , cystectomy , obstetrics , cancer , population , environmental health , bladder cancer , genetics , biology
BACKGROUND Ovarian tumors of borderline malignancy have a less aggressive behavior and tend to occur at a younger age than their invasive counterparts. The role and extent of fertility‐sparing conservative treatments is under continuous evaluation. METHODS The current study was a retrospective review of 82 patients with confirmed borderline tumors diagnosed over a 25‐year period, with special focus on fertility‐associated issues. RESULTS Follow‐up was available for 96% of the patients, for a total of 357 women‐years of follow‐up. Thirty‐nine patients underwent conservative management. Of these, only three patients had a contralateral recurrence. Two of the three again opted for conservative management and were without evidence of disease at last follow‐up. Seventeen patients did benefit from contralateral ovarian dissection either by cystectomy or oophorectomy because of contralateral benign or borderline disease. Eleven patients had received or were scheduled to receive ovulation induction. Five patients were diagnosed during the evaluation, and another two were diagnosed so soon after the initiation of ovulation induction that a causative relationship appeared to be unlikely. Six patients were diagnosed during ongoing pregnancies. Twenty‐two pregnancies were achieved in 15 patients after conservative treatment. No influence of the disease or its treatment on the pregnancy (or vice versa) was observed during a mean follow‐up of 69 months. CONCLUSIONS Data are accumulating that indicate conservative fertility‐sparing disease management is adequate treatment for patients with borderline tumors. Available data indicate that in these patients fertility, pregnancy outcome, and survival remain excellent. Cancer 1998;82:141‐6. © 1998 American Cancer Society.