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Adult Wilms' tumor
Author(s) -
Orditura Michele,
Vita Ferdinando De,
Catalano Giuseppe
Publication year - 1997
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19971115)80:10<1961::aid-cncr13>3.0.co;2-w
Subject(s) - medicine , wilms' tumor , pathology
BACKGROUND Wilms' tumor in an adult is rare and no treatment guidelines have been established, although all authors recommend aggressive therapy based on surgery, radiotherapy, and multiagent chemotherapy. METHODS The authors describe a case of Wilms' tumor in a 23‐year‐old woman who developed hepatic and pulmonary metastases after undergoing nephrectomy. Treatment was initiated with carboplatin, etoposide, ifosfamide, and epirubicin combination chemotherapy and irradiation of the tumor bed, lungs, and liver. RESULTS Metastatic workup was negative 41 months after suspension of chemoradiotherapy. Hematologic toxicity was high, but was manageable with adequate supportive care. CONCLUSIONS Because this multimodal treatment, which included a chemotherapeutic regimen with single agents generally used in patients with recurrent disease, had impressive activity in this patient with an advanced adult Wilms' tumor, the issue of further investigation of this alternative schedule is raised. Cancer 1997; 80:1961‐5. © 1997 American Cancer Society.