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Aspiration and imprint cytopathology of salivary duct carcinoma
Author(s) -
Domson Kelly K.,
Wakely, Paul E.
Publication year - 1997
Publication title -
cancer cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19971025)81:5<281::aid-cncr5>3.0.co;2-q
Subject(s) - cytopathology , medicine , cribriform , pathology , salivary duct carcinoma , fine needle aspiration , comedo , biopsy , carcinoma , cytology , histology , cancer , breast cancer , ductal carcinoma
BACKGROUND Salivary duct carcinoma (SDC) is a highly malignant primary epithelial neoplasm of the salivary glands. The histology of this lesion resembles that of cribriform and comedo‐type intraductal carcinoma of the breast, yet the cytopathology of salivary duct carcinoma has been described in only a few instances in the past. METHODS The authors report two cases of SDC diagnosed by fine‐needle aspiration biopsy and one case imprinted after resection. The cytologic features that may permit diagnosis of this entity are described. RESULTS Cytologic features include variably cellular smears containing loose clusters of cribriform and glandlike aggregates; monomorphic polygonal cells with round‐to‐oval nuclei; abundant, finely granular cytoplasm; indistinct nucleoli; and variable necrosis. CONCLUSIONS The cytologic findings for SDC are relatively unique and may allow for its specific diagnosis on aspiration cytopathology. Cancer (Cancer Cytopathol) 1997; 81:281‐6. © 1997 American Cancer Society.