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The current state of renal cell carcinoma grading
Author(s) -
Goldstein Neal S.
Publication year - 1997
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19970901)80:5<977::aid-cncr22>3.0.co;2-s
Subject(s) - grading (engineering) , medicine , renal cell carcinoma , kidney cancer , oncology , civil engineering , engineering
BACKGROUND The grading of renal cell carcinoma (RCC) has a long history. Currently, there are several grading systems in use throughout the world. There is no consensus regarding which grading system is optimal. METHODS A review of the patient outcome cutpoints of several RCC grading systems was conducted to determine the advantages and disadvantages of the different systems. RESULTS Almost all authors who have conducted studies of RCC grading agree that it is useful in determining prognosis. The patient outcome cutpoints vary among studies, depending on which grading system is used. Different patient outcome cutpoints have been obtained with the same grading system but different patient groups. CONCLUSIONS The ideal RCC grading system has yet to be developed. Any new grading system should be predicated on a study that has separated RCC into the new genetically based subtypes. A new system should also be based on patient outcome, be large enough to account for other prognostic parameters, and be based on reproducible histologic criteria that are easy to apply. Cancer 1997; 80:977‐80. © 1997 American Cancer Society.