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Erythropoietin reduces anemia and transfusions after chemotherapy with paclitaxel and carboplatin
Author(s) -
Dunphy Frank R.,
Dunleavy Teresa L.,
Harrison Bruce R.,
Boyd James H.,
Varvares Mark A.,
Dunphy Cherie H.,
Rodriguez Jack J.,
McDonough Erin M.,
Minster Jeffrey R.,
McGrady Murray D.
Publication year - 1997
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19970415)79:8<1623::aid-cncr28>3.0.co;2-z
Subject(s) - carboplatin , medicine , chemotherapy , anemia , erythropoietin , hemoglobin , surgery , paclitaxel , carcinoma , gastroenterology , cisplatin
BACKGROUND The authors report on anemia observed during preoperative paclitaxel and carboplatin chemotherapy in patients with advanced head and neck carcinoma and discuss how the use of recombinant human erythropoietin (r‐HuEPO) ameliorates this anemia, reducing the need for subsequent packed red blood cell (PRBC) transfusions. METHODS Response to r‐HuEPO was defined as reduced hemoglobin fall during preoperative chemotherapy and reduced transfusion requirements during surgery. Thirty‐six patients with advanced head and neck carcinoma were evaluable after treatment with preoperative chemotherapy using paclitaxel and carboplatin. Group 1 was comprised of 14 patients who empirically received r‐HuEPO at a dose of 150 U/kg 3 times per week for 3 weeks; in patients deemed nonresponders, the dose was increased to 300 U/kg and 450 U/kg in the subsequent courses. Group 2 was comprised of 22 patients who did not receive r‐HuEPO. RESULTS During preoperative chemotherapy, the mean hemoglobin fall was 0.5 g/dL in Group 1 ( P = 0.40). In Group 2 there was a statistically significant mean hemoglobin fall of 3.3 g/dL ( P < 0.0001). There was also a nonstatistically significant trend toward fewer PRBC transfusions: none of 14 patients (0%) in Group 1 versus 4 of 22 patients (18%) in Group 2 ( P = 0.141). CONCLUSIONS A significant fall in hemoglobin and an increase in the need for transfusions were observed in head and neck carcinoma patients receiving carboplatin and paclitaxel chemotherapy prior to surgery. Empiric r‐HuEPO therapy appeared to prevent anemia and reduced the need for PRBC transfusions. Cancer 1997; 79:1623‐8. © 1997 American Cancer Society.