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Immunosuppressive therapy for hypoplastic myelodysplastic syndrome
Author(s) -
Biesma Douwe H.,
van den Tweel Jan G.,
Verdonck Leo F.
Publication year - 1997
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19970415)79:8<1548::aid-cncr16>3.0.co;2-y
Subject(s) - medicine , bone marrow , myelodysplastic syndromes , dysplasia , surgery , bone marrow transplantation , transplantation , oncology
BACKGROUND Hypoplastic myelodysplastic syndrome (MDS) is characterized by dysplasia and hypocellularity. The treatment of choice for young patients is bone marrow transplantation. METHODS This report describes the effect of immunosuppressive therapy in two patients with hypoplastic MDS for whom no suitable bone marrow donors were available. RESULTS Both patients had no human lymphocyte antigen‐identical siblings and no suitable matched unrelated donor could be found. They received cyclosporin A (CsA), antithymocyte globulin (ATG), or a combination of the two. Treatment with CsA, ATG, or the combination led to clinical improvement (resolution of transfusion requirement), increase of bone marrow cellularity, and the disappearance of dysplastic characteristics in the two patients with hypoplastic MDS. At the time of recurrence, this disease was still responsive to immunosuppressive therapy. CONCLUSIONS Treatment with ATG and CsA can be an attractive alternative for patients with hypoplastic MDS for whom there is no possibility of bone marrow transplantation. Cancer 1997; 79:1548‐51. © 1997 American Cancer Society.