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Soluble interleukin‐2 receptor serum level as a predictor of locoregional control and survival for patients with head and neck carcinoma
Author(s) -
Tartour Eric,
Deneux Laurent,
Mosseri Veronique,
Jaulerry Christian,
Brunin Françoise,
Point Daniel,
Validire Pierre,
Dubray Bernard,
Fridman Wolf Herman,
Rodriguez José
Publication year - 1997
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19970401)79:7<1401::aid-cncr18>3.0.co;2-3
Subject(s) - medicine , univariate analysis , head and neck squamous cell carcinoma , multivariate analysis , oncology , carcinoma , gastroenterology , lymph node , head and neck , basal cell , prospective cohort study , head and neck cancer , cancer , surgery
BACKGROUND The diagnosis and follow‐up of head and neck carcinoma patients are based exclusively on clinical staging, which cannot always predict clinical outcome accurately. Because oral squamous cell carcinomas produce interleukin (IL)‐6 and tumor necrosis factor (TNF)‐α and express IL‐2 receptors, the authors assessed the prognostic value of the serum levels of these markers. METHODS Serum levels of IL‐6, TNF‐α, soluble IL‐2 receptors (s‐IL‐2‐R), and acute phase proteins were measured at the time of diagnosis in a prospective study of 85 patients with primary squamous cell carcinoma of the head and neck. The influence of each clinical and laboratory parameter on locoregional control and survival was analyzed. RESULTS At presentation, a relationship was observed between advanced tumor (T) classification and high serum levels of CRP ( P = 0.0015) and s‐IL‐2‐R ( P < 0.05). A high lymph node (N) classification was significantly associated with elevated serum IL‐6 ( P = 0.01) and CRP levels ( P = 0.0002). In the univariate analysis, T classification, N classification, performance status, Prognostic Inflammatory and Nutritional Index, and serum s‐IL‐2‐R level were significantly correlated with both locoregional control and survival. Multivariate analysis showed that the only significant prognostic factors related independently to locoregional control were N classification ( P = 0.02) and serum s‐IL‐2‐R level ( P = 0.02). In a Cox multivariate analysis, serum s‐IL‐2‐R level was found to be the most predictive factor of survival ( P = 0.0001). CONCLUSIONS This study shows that serum s‐IL‐2‐R level at the time of diagnosis represents a new independent prognostic variable for predicting the risk of locoregional recurrence and survival for patients with head and neck squamous cell carcinoma. Cancer 1997; 79:1401‐8. © 1997 American Cancer Society.