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N‐terminal peptide of Type III procollagen
Author(s) -
Plebani Mario,
Basso Daniela,
Roveroni Giovanni,
Paoli Massimo De,
Galeotti Fabrizio,
Corsini Augusto
Publication year - 1997
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/(sici)1097-0142(19970401)79:7<1299::aid-cncr5>3.0.co;2-c
Subject(s) - medicine , terminal (telecommunication) , peptide , procollagen peptidase , biochemistry , biology , computer science , telecommunications
BACKGROUND The first step of colorectal carcinoma spread depends on the ability of the tumor cells to degrade and invade the extracellular matrix (ECM). The objectives of the current study were to evaluate the serum pattern of laminin, C‐terminal peptide of Type I (PIP), and N‐terminal peptide of Type III (PIIIP) procollagens, markers of ECM synthesis, in the follow‐up of patients after resection for colorectal carcinoma and to evaluate their role in predicting local recurrence or metastases. METHODS A total of 32 patients who had undergone resection for colorectal carcinoma were followed for a median period of 24 months (range, 6‐36 months). Every 3 months, laminin, PIP, and PIIIP were measured in the sera together with the tumor markers carcinoembryonic antigen (CEA), CA 19‐9, and tissue plasminogen activator (TPA). Twenty‐one patients (Group 1) had no signs of recurrence, whereas the remaining 11 (Group 2) developed hepatic (n = 7) or pulmonary (n = 4) metastases. RESULTS No variations were observed in either group for laminin, CEA, CA 19‐9, or TPA, whereas significant increases in PIP and PIIIP were observed in both groups 3 months after surgery. The increase in PIP and PIIIP at the 3‐month follow‐up was significantly greater in Group 1 than in Group 2. The difference between values at 3 months and basal values enabled a discrimination between Group 1 and Group 2, with a sensitivity of 36% and 91% and a specificity of 71% and 71% for PIP and PIIIP, respectively. CONCLUSIONS The authors believe PIIIP is useful as an early prognostic indicator of recurrence in the follow‐up of patients who have undergone radical resection for colorectal carcinoma. Cancer 1997; 79:1299‐303. © 1997 American Cancer Society.